actIvators of Glutamate-dependent acId resIstance sYstem allevIate deleterIous effects of YIdc depletIon In EschErichia coli
نویسنده
چکیده
1department of molecular microbiology, Institute of molecular cell biology, vu university amsterdam, the netherlands, 2swammerdam Institute for life sciences, molecular microbial physiology, university of amsterdam, amsterdam, the netherlands, 3Istituto di biologia e patologia molecolari, cnr, dipartimento di scienze biochimiche, università di roma sapienza, roma, Italy, 4 department of microbiology and Immunology, university of otago, dunedin, new Zealand, 5department of molecular microbiology, Groningen biomolecular sciences and biotechnology Institute, university of Groningen, haren, the netherlands, and 6Istituto pasteur – fondazione cenci bolognetti, dipartimento di scienze biotecnologie medico-chirurgiche, universit di roma sapienza, latina, Italy.
منابع مشابه
Activators of the glutamate-dependent acid resistance system alleviate deleterious effects of YidC depletion in Escherichia coli.
The function of the essential inner membrane protein (IMP) YidC in Escherichia coli has been studied for a limited number of model IMPs and primarily using targeted approaches. These studies suggested that YidC acts at the level of insertion, folding, and quality control of IMPs, both in the context of the Sec translocon and as a separate entity. To further our understanding of YidC's role in I...
متن کاملDifferential effect of YidC depletion on the membrane proteome of Escherichia coli under aerobic and anaerobic growth conditions.
YidC of Escherichia coli belongs to the evolutionarily conserved Oxa1/Alb3/YidC family. Members of the family have all been implicated in membrane protein biogenesis of respiratory and energy transducing proteins. The number of proteins identified thus far to require YidC for their membrane biogenesis remains limited and the identification of new substrates may allow the elucidation of properti...
متن کاملMechanisms of acid resistance in enterohemorrhagic Escherichia coli.
Enterohemorrhagic strains of Escherichia coli must pass through the acidic gastric barrier to cause gastrointestinal disease. Taking into account the apparent low infectious dose of enterohemorrhagic E. coli, 11 O157:H7 strains and 4 commensal strains of E. coli were tested for their abilities to survive extreme acid exposures (pH 3). Three previously characterized acid resistance systems were ...
متن کاملFunctional overlap but lack of complete cross-complementation of Streptococcus mutans and Escherichia coli YidC orthologs.
Oxa/YidC/Alb family proteins are chaperones involved in membrane protein insertion and assembly. Streptococcus mutans has two YidC paralogs. Elimination of yidC2, but not yidC1, results in stress sensitivity with decreased membrane-associated F(1)F(o) ATPase activity and an inability to initiate growth at low pH or high salt concentrations (A. Hasona, P. J. Crowley, C. M. Levesque, R. W. Mair, ...
متن کاملConserved negative charges in the transmembrane segments of subunit K of the NADH:ubiquinone oxidoreductase determine its dependence on YidC for membrane insertion.
All members of the Oxa1/Alb3/YidC family have been implicated in the biogenesis of respiratory and energy transducing proteins. In Escherichia coli, YidC functions together with and independently of the Sec system. Although the range of proteins shown to be dependent on YidC continues to increase, the exact role of YidC in insertion remains enigmatic. Here we show that YidC is essential for the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012